GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| UCEC | cis | rs9815354 | 1 | rs1717031 | chr3:41905791 | ULK4 | chr3:41288091-42003660:- | 0.53 | 6.52 | 9.73E-10 | Diastolic blood pressure |
| UCEC | cis | rs9815354 | 1 | rs1717033 | chr3:41910216 | ULK4 | chr3:41288091-42003660:- | 0.53 | 6.52 | 9.73E-10 | Diastolic blood pressure |
| UCEC | cis | rs17433780 | 1 | rs17433780 | chr1:89474818 | GBP3 | chr1:89472367-89488549:- | 0.67 | 10.25 | 4.68E-19 | Carotid intima media thickness |
| UCEC | cis | rs1432723 | 1 | rs17533269 | chr5:155314746 | PPP1R2P3 | chr5:156277549-156279539:+ | 0.42 | 4.67 | 6.67E-6 | Obesity-related traits |
| UCEC | cis | rs1432723 | 1 | rs17617120 | chr5:155299213 | PPP1R2P3 | chr5:156277549-156279539:+ | -0.39 | -4.38 | 2.17E-5 | Obesity-related traits |
| UCEC | cis | rs1432723 | 1 | rs17617422 | chr5:155317252 | PPP1R2P3 | chr5:156277549-156279539:+ | -0.41 | -4.78 | 4.13E-6 | Obesity-related traits |
| UCEC | cis | rs17646946 | 1 | rs17646946 | chr1:152062767 | THEM4 | chr1:151846060-151882113:- | 0.53 | 4.77 | 4.34E-6 | Common traits (Other) |
| UCEC | cis | rs10935120 | 1 | rs17694011 | chr3:134213981 | ANAPC13 | chr3:134196547-134204865:- | 0.4 | 4.64 | 7.4E-6 | Height |
| UCEC | cis | rs60843830 | 1 | rs17713396 | chr2:227201 | SH3YL1 | chr2:218138-264810:- | -0.49 | -6.56 | 7.97E-10 | Spherical equivalent (joint main effects and education interaction) |
| UCEC | cis | rs60843830 | 1 | rs17713729 | chr2:249092 | SH3YL1 | chr2:218138-264810:- | -0.48 | -6.53 | 9.12E-10 | Spherical equivalent (joint main effects and education interaction) |
| UCEC | cis | rs60843830 | 1 | rs17714252 | chr2:285471 | SH3YL1 | chr2:218138-264810:- | -0.42 | -5.87 | 2.63E-8 | Spherical equivalent (joint main effects and education interaction) |
| UCEC | cis | rs10935120 | 1 | rs1814336 | chr3:134200823 | ANAPC13 | chr3:134196547-134204865:- | 0.39 | 4.43 | 1.81E-5 | Height |
| UCEC | cis | rs10935120 | 1 | rs1814337 | chr3:134200682 | ANAPC13 | chr3:134196547-134204865:- | 0.39 | 4.45 | 1.67E-5 | Height |
| UCEC | cis | rs950169 | 1 | rs1818950 | chr15:84722521 | LOC388152 | chr15:84867600-84898920:- | -0.46 | -4.85 | 3.07E-6 | Schizophrenia |
| UCEC | cis | rs10461617 | 1 | rs1833896 | chr5:56097669 | C5orf35 | chr5:56205103-56213010:+ | 0.47 | 5.58 | 1.06E-7 | Type 2 diabetes |